Back خلية رغوية Arabic Pěnitá buňka Czech Schaumzelle German Célula espumosa Spanish سلولهای فوم Persian Cellule spumeuse French Célula escumosa Galician תאי קצף HE Foam cells Italian 泡沫細胞 Japanese
| Foam cell | |
|---|---|
 Foam cells (one indicated by arrows) visible in the finger-like projections into the gallbladder lumen in a case of cholesterolosis | |
| Details | |
| Precursor | monocyte-derived macrophage |
| Identifiers | |
| MeSH | D005487 |
| FMA | 83586 |
| Anatomical terms of microanatomy | |
Foam cells, also called lipid-laden macrophages, are a type of cell that contain cholesterol. These can form a plaque that can lead to atherosclerosis and trigger myocardial infarction and stroke.[1][2][3]
Foam cells are fat-laden cells with a M2 macrophage-like phenotype. They contain low density lipoproteins (LDL) and can be rapidly detected by examining a fatty plaque under a microscope after it is removed from the body.[4] They are named because the lipoproteins give the cell a foamy appearance.[5]
Despite the connection with cardiovascular diseases they might not be inherently dangerous.[6]
Some foam cells are derived from smooth muscle cells and present a limited macrophage-like phenotype.[7][8][9]
- ^ Hotamisligil GS (April 2010). "Endoplasmic reticulum stress and atherosclerosis". Nature Medicine. 16 (4): 396–399. doi:10.1038/nm0410-396. PMC 2897068. PMID 20376052.
- ^ Yu XH, Fu YC, Zhang DW, Yin K, Tang CK (September 2013). "Foam cells in atherosclerosis". Clinica Chimica Acta; International Journal of Clinical Chemistry. 424: 245–252. doi:10.1016/j.cca.2013.06.006. PMID 23782937.
- ^ Oh J, Riek AE, Weng S, Petty M, Kim D, Colonna M, et al. (April 2012). "Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation". The Journal of Biological Chemistry. 287 (15): 11629–11641. doi:10.1074/jbc.M111.338673. PMC 3320912. PMID 22356914.
- ^ Cite error: The named reference
pmid21076992was invoked but never defined (see the help page). - ^ "Foam cells - Latest research and news | Nature".
- ^ Cite error: The named reference
:4was invoked but never defined (see the help page). - ^ Li Y, Zhu H, Zhang Q, Han X, Zhang Z, Shen L, et al. (November 2021). "Smooth muscle-derived macrophage-like cells contribute to multiple cell lineages in the atherosclerotic plaque". Cell Discovery. 7 (1): 111. doi:10.1038/s41421-021-00328-4. PMC 8608914. PMID 34811358.
- ^ Gui Y, Zheng H, Cao RY (2022). "Foam Cells in Atherosclerosis: Novel Insights Into Its Origins, Consequences, and Molecular Mechanisms". Frontiers in Cardiovascular Medicine. 9: 845942. doi:10.3389/fcvm.2022.845942. PMC 9043520. PMID 35498045.
- ^ Pryma CS, Ortega C, Dubland JA, Francis GA (April 2019). "Pathways of smooth muscle foam cell formation in atherosclerosis". Current Opinion in Lipidology. 30 (2): 117–124. doi:10.1097/MOL.0000000000000574. PMID 30664015. S2CID 58633787.